Exercise as a Treatment for Cognitive Decline in Older Adults: The Role of Growth Factors and Inflammatory Cytokines
Year: 2021
Type: dissertation
Study design: Systematic Review
Abstract: The purpose of this thesis was to investigate the effects that exercise modalities have on neurotrophic and inflammatory blood markers and cognitive outcomes in older adults. A systematic review and meta-analysis were completed. The included studies illustrated that most of the literature evaluated the effect of aerobic exercise interventions on systemic concentrations of the blood marker brain-derived neurotrophic factor (BDNF). The review found that aerobic exercise increases BDNF and resistance training increases insulin-like growth factor 1 (IGF-1). Interventions with sex-specific cohorts presented advantages in males for blood marker and cognitive outcomes compared to females. One of three included interventions decreased C-reactive protein (CRP). This thesis demonstrated the presence of modality-specific outcomes of exercise on blood markers and presents a targeted review of the literature evaluating exercise, cognition, and blood markers.
Author: Titus, Joshua A
Language: English
Topic: Physical Activity and Health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1429218087, G4101346169, G7433331608
OpenAlex ID: W7019112303