Impact of smoking status on mortality in STEMI patients undergoing mechanical reperfusion for STEMI
Year: 2026
Type: article
Study design: Observational Study
Abstract: The so-called “smoking paradox”, conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS–STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001)
Authors: De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Zimbakov, Zan, Čerček, Miha
Institutions: University of Sassari, Azienda Ospedaliero Universitaria di Sassari, Assiut University Hospitals, Assiut University, Bursa City Hospital, Universidade Federal de Pernambuco, Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences, Ljubljana University Medical Centre
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7019570232
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