Impact of FAAH genetic variation on fronto-amygdala function during emotional processing: A replication and extension study
Year: 2023
Type: preprint
Study design: Observational Study
Abstract: The present study aims to (1) replicate the findings of differential fronto-amygdala coupling depending on FAAH C385A genotype (rs324420) as reported in Gärtner et al. (2019). Furthermore, the study aims to extent these findings and investigates 2) habituation patterns in fronto-amygdala circuits depending on FAAH genotypes. Given the failure to replicate findings from candidate gene studies (e.g., Border et al., 2019), which partly relies on the small effect sizes of single candidate genes, we further 3) investigate whether a polygenic score (PGS) comprising genetic variation from the endocannabinoid system (PGS 1), the serotonin system (PGS 2) and anxiety-related genetic variation derived from recent GWAS findings (PGS 3) explains a larger amount of variance in the investigated phenotypes than single polymorphisms.
Source: OSF Preprints (OSF Preprints)
Authors: Burkhard Brocke, Henrik Walter, Anne Gärtner, Denise Dörfel, Susanne Erk, Alexander Strobel
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7019915947