Involvement of Oxidative Stress in the Pathogenesis of Schizophrenia:focus on Nox Enzymes
Year: 2011
Type: dissertation
Abstract: The imbalance between the production of reactive oxygen species (ROS) and the cellular\nantioxidant defence, determines a situation called “oxidative stress”. ROS react and oxidize\ncellular components, such as proteins or DNA, leading to cell death and severe tissue damage.\nThe central nervous system (CNS) is particularly sensitive to oxidative stress because of high\noxygen consumption, low antioxidant defense and abundance of lipids, which are prone to\noxidation. For this reason a variety of CNS diseases have an oxidative stress component. In the\nCNS, NOX NADPH oxidases are increasingly recognized as major sources of ROS. Among the\nseven existing isoforms, the presence of NOX1, NOX2, NOX3 and NOX4 transcripts has been\ndetected in total brain samples. In addition, several immunohistological and in vitro studies\nhave investigated the expression of NOX isoforms in specific CNS regions and cells. From\nthese studies, it appears that NOX1, NOX2 and NOX4 are present in microglia, neurons and\nastrocytes. Although the physiological role of constitutive NOX expression in the brain is still\npoorly understood, several researches suggest that they are involved in brain development\nand function, but most studies indicate that an excessive production of ROS by NOX enzymes\nparticipates to the progression of various neurological and psychiatric diseases. The aim of this\nresearch project was to investigate the role of NOX2 in the pathogenesis of schizophrenia.
Author: SCHIAVONE, STEFANIA
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7020150693