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Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

Year: 2010
Type: article
Abstract: Infectious Amyloid? Patients with Alzheimer's disease have characteristic lesions in the brains associated with masses of polymerized protein called β-amyloid. Recently, evidence from mouse models of Alzheimer's disease shows that brain extracts containing β-amyloid can “infect” otherwise healthy animals when injected directly into their brains. Eisele et al. (p. 980 , published online 21 October; see the Perspective by Kim and Holtzman ) extend these findings to show that when mice are injected in other parts of their bodies with similar brain extracts after several months, they also develop amyloidosis within their brains.
Source: Science
DOI: 10.1126/science.1194516
Authors: Yvonne S. Eisele, Ulrike Obermüller, Götz Heilbronner, Frank Baumann, Stephan A. Kaeser, Hartwig Wolburg, Lary C. Walker, Matthias Staufenbiel, Mathias Heikenwalder, Mathias Jucker
Institutions: German Center for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Emory University, Emory National Primate Research Center, Novartis (Switzerland), Novartis Institutes for BioMedical Research, University Hospital Zurich
Language: English
Open Access status: green
OpenAlex ID: W1493986974
FWCI: 16.51
Cites: 15
Cited by: 582
Related to: 10