Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
Year: 2018
Type: article
Abstract: Significance Parkinson’s disease is characterized by the accumulation of amyloid deposits in dopaminergic neurons, mainly composed of the protein α-synuclein. The disordered nature of α-synuclein and its complex aggregation reaction complicate the identification of molecules able to prevent or revert the formation of these inclusions and the subsequent neurodegeneration. By exploiting a recently developed high-throughput screening assay, we identified SynuClean-D, a small compound that inhibits α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.
Authors: Jordi Pujols, Samuel Peña-Díaz, Diana F. Lázaro, Francesca Peccati, Francisca Pinheiro, Danilo González, Anita Carija, Susanna Navarro, María Conde-Giménez, Jesús García, Salvador Guardiola, Ernest Giralt, Xavier Salvatella, Javier Sancho, Mariona Sodupe, Tiago Fleming Outeiro, Esther Dalfó, Salvador Ventura
Institutions: Universitat Autònoma de Barcelona, Universitätsmedizin Göttingen, Centre National de la Recherche Scientifique, Sorbonne Université, Laboratoire de Chimie Théorique, Universidad de Zaragoza, Instituto de Biocomputación y Física de Sistemas Complejos, Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Universitat de Barcelona, Institució Catalana de Recerca i Estudis Avançats, Max Planck Institute of Experimental Medicine, Newcastle University, Universitat de Vic - Universitat Central de Catalunya
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Fundació la Marató de TV3, Deutsche Forschungsgemeinschaft, Ministerio de Economía y Competitividad, Institució Catalana de Recerca i Estudis Avançats, Universitat de Barcelona, Gobierno de Aragón, Consejo Superior de Investigaciones Científicas, Instituto de Salud Carlos III, Secretaría de Estado de Investigación, Desarrollo e Innovación, European Regional Development Fund, European Social Fund, H2020 European Research Council
OpenAlex ID: W2893729429