Year: 2022
Type: dissertation
Abstract: Plants produce a variety of phytohormones that control important physiological processes such as growth and stress tolerance.Many traditional plant hormones and specialized metabolites were shown to have biological activities in humans or animal models.For example, the plant hormones salicylic acid (SA) and abscisic acid (ABA) have shown promising anti-inflammatory effects, suggesting these phytohormones can be used as potential multifunctional nutraceuticals against inflammation-associated diseases, metabolic syndrome (MetS) in particular.Interestingly, animal cells have long been known to produce SA and ABA.However, the physiological relevance of these endogenous molecules is poorly understood.Although their antiinflammatory activities point to involvement in immune homeostasis, the functional characterization of these endogenous molecules has been hampered because of a lack of knowledge about their metabolism and signaling pathways.Therefore, this PhD research aimed to gain insight into the role of endogenous SA and ABA by exploiting these hormones' known metabolic and signaling pathways in other organisms like plants and bacteria.Chapter 1 introduces the current state-of-the-art of phytohormones as anti-inflammatory and pro-metabolic compounds against diseases relevant to MetS.Also, we present how these bioactive phytohormones can be generated endogenously and through the gut microbiome.Chapter 2 introduces thymic T cell development and function in the context of immunometabolism.As in the results section (Chapter 3) we mainly focus on thymic T cell development and diverse T cell subsets are closely tied to metabolic homeostasis, this introductory chapter mainly focuses on these aspects of the immune system.VII het DSS-geïnduceerde colitismodel omwille van specifieke omgevingsfactoren eigen aan verschillende muisfaciliteiten, hebben we eerst de eerder gepubliceerde resultaten die een profylactisch effect van ABA in het DSS-geïnduceerde colitismodel aantonen proberen te valideren door de DSS-geïnduceerde colitis te volgen in ABA behandelde wild-type muizen (Hoofdstuk 5).We konden het eerder gerapporteerdebeschermend effect van ABA tegen DSS-geïnduceerde colitis bij muizen echter niet aantonen, en beschrijven mogelijke redenen voor de geobserveerde discrepantie.Ten slotte bespreken we de verkregen wetenschappelijke resultaten en weerspiegelen we de technische uitdagingen waarmee we werden geconfronteerd.Dit promotieonderzoek vormt een eerste aanzet tot en proof-of-concept voor toekomstig plantenhormoononderzoek in zoogdieren.
Author: Kim, Seo Woo
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7025357607