경구 당섭취후 혈장 아밀린농도의 변화에 관한 연구
Year: 1993
Type: article
Study design: Observational Study
Abstract: Background : Peripheral insulin resistance, increased hepatic glucose production, and impaired insulin secretion are the three characteristic features that underlying the deranged carbohydrate metabolism in type II diabetes. Islet amyloid polypeptide (IAPP, amylin) is a 37-aminoacid peptide that was isolated from pancreatic islet amyloid of type II diabetic and insulinoma patients. Recent interest has focused on the potenital role of amylin in the pathogenesis of type II diabetes.\n\nMethod ： We determined amylin and C-peptide response in plasma to oral glucose administration in 5 patients with type I diabetes (Group 1), 8 patients with type II diabetes (Group 2), and 9 normal controls (Group 3), by specific amylin radioimmunoassay methods. In group I, II, III，ages (mean土SD> were 18士6 years, 43 ±14 years, 39±15 years respectively. BMI (mean土 SD) were 16.8±2그’ 21.5±2.3, 21.2±'3.8 respectively.\n\nResult ：\n\n1) Plasma C-peptide levels after oral administration of 75 g glucose were significantly (p<0.05) higher in patients with type II diabetes and normal control groups than in patients with type I diabetes.\n\n2) Plasma amylin concentrations after oral administration of 75 g glucose showed no significant difference between in patients with type II diabetes and in normal control groups. But plasma amylin concentrations in patients with type II diabetes and in normal control groups were significantly (p<0.05) higher than in patients with type I diabetes.\n\n3) There were significant {p< 0.01) correlations {r2—0. 47) between plasma amylin and C-peptide concentration.\n\nConclusion ： These results suggest that amylin is cosecreted with insulin and C-peptide in response to a glucose load. But there are no differences in plasma amylin concentrations between type II diabetic and normal control subjects. Therefore, further studies will be required to determine whether amylin is a physiological regulator of carbohydrate metabolism in human.\nKey Words: Insulin resistance, Type II diabetes, Amylin
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7025896084