Diseño y desarrollo de un test de medicina preventiva en el ámbito del envejecimiento celular
Year: 2023
Type: dissertation
Abstract: Cellular ageing is a natural process that occurs over time and is determined by a combination of physical, environmental, social, and genetic factors, that result in a series of structural and functional changes that lead to a significant increase in degenerative diseases. However, this ageing process appears to be highly heterogeneous among individuals, as population studies have highlighted the existence of centenarian human populations, implying the presence of certain factors that may play an important role in increasing or reducing life expectancy. In particular, studies in these populations indicate that genetic factors may be involved in differences in the efficiency of cellular damage repair and elimination observed among different individuals, thus affecting their longevity. In this study, we extensively investigate the scientific literature on genetic factors involved in cellular ageing with the aim of developing a personalized report that indicates the relevance of an individual's genotype to their longevity. To obtain the genotype, we use the microarray Axiom PMDA array of Thermo Fisher platform, which encompasses over 850,000 genetic variants relevant to health and well-being. Our massive analysis of genetic variants involves the characterization of single-point variations in DNA, known as polymorphisms or SNPs (single nucleotide polymorphisms), which are associated with certain risks or predispositions. For each SNP, we obtain information on the two copies inherited from the father and inherited from the mother, and determine in each case whether the combination of variants is neutral, favourable, or unfavourable to longevity. Our report AboutMe Longevity results in personalized recommendations derived from the analysis of 18 genetic variants in 17 different genes involved in molecular mechanisms associated with cellular ageing: genomic instability, telomere shortening, cellular senescence, DETOX capacity, disruption of intercellular communication, dysregulation of nutrient sensing, and sleep pattern. AboutMe Longevity represents a novel test in the preventive medicine market that allows individuals to understand the contribution of their genetic factors to their life expectancy, enabling them to make lifestyle changes to reduce the rate of cellular ageing, improve their quality of life, and consequently increase their longevity.
Author: Cubiles Cid, Pablo
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7027878656