Isolation Rate and Antifungal Susceptibility Patterns of Bloodstream Candida Species in a North Indian Hospital Setting between 2017-2021
Year: 2025
Type: article
Abstract: Background: Candidemia is an increasingly important healthcare-associated fungal infection that is associated with high morbidity and mortality. The epidemiology of candidemia varies according to geographical region, period and the population involved. An increased incidence of non-albicans candidemia has been reported in recent studies. Aim: To study the prevalence of Candida species and their susceptibility profile over a period of five years (2017– 2021). Material and Methods: This retrospective study was performed in the microbiology laboratory. Specimens were collected and culture was performed using the BacTAlert3D / BacTec culture system. All the isolates were identified and their antifungal susceptibility testing was performed. Results: Year-wise positivity rates of candidemia were 0.85%, 0.68%, 0.73%, 0.82% and 0.71%. Majority of the isolates were from the age group 51-60 years with male predominance. Candida tropicalis was the most common species followed by C. albicans & C. parapsilosis. Candida isolates showed good susceptibility to Amphotericin B & Echinocandins whereas increased resistance to azoles (20-30%) was observed in C. tropicalis & C. parapsilosis. Conclusion: The emergence of a few Candida species, which were not previously isolated is alarming. NAC being more resistant / intrinsically resistant to fluconazole strengthens the need for antifungal susceptibility testing on a priority basis.
Source: JK Science
Authors: Veenu Gupta, Rama Gupta, Manisha Aggarwal, Jyoti Chaudhary, Menal Gupta
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7029498999
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