Work

Micellar Structures of PAAm-b-PEO-b-PAAm Triblock Copolymers: Formation, Morphology, and Application as Drug Carries

Year: 2012

Type: dissertation

Abstract: The micellization of asymmetric PAAm-b-PEO-b-PAAm triblock copolymers (TBCs) with increasing length of chemically complementary polyacrylamide and poly(ethylene oxide) blocks was studied using static light scattering, photography, UV-Vis spectroscopy and TEM. The formation of “hairy-type” and “flower-like” micelles was established in dilute aqueous and aqueous/ethanol solutions. The “hairy” micelles contained a “core” comprised cooperatively interacting PEO and PAAm segments and “corona” formed by unbound units of longer PAAm blocks. Appearance of the “flower-like” micelles was conditioned by insolubility of PAAm blocks. Stability of the “flower-like” micelles was higher than that of the "hairy-type" ones. Significant encapsulation of a model drug prednisolon by TBC micelles was established. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/34795

Source: Electronic Sumy State University Institutional Repository (Sumy State University)

Authors: Zheltonozhskaya, T.V., Partsevskaya, S.V., Klymchuk, D.O

Institutions: Taras Shevchenko National University of Kyiv, National Academy of Sciences of Ukraine

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W7030177991

Cites:

Cited by:

Related to: 10