Systematische profilering van functionele microRNA-132 targets en het therapeutische potentieel voor de ziekte van Alzheimer
Year: 2022
Type: dissertation
Abstract: Previous work has shown that microRNA profiles in the brains of Alzheimer's disease (AD) patients change with the progression of the pathology, suggesting a possible role for microRNAs in AD. Of particular interest is the brain-enriched microRNA-132 (miR-132), whose levels are significantly and robustly decreased in AD patient brain. Moreover, this microRNA has been associated with several molecular pathways that are also affected in AD, such as immune response, neuronal survival and memory formation. By restoring de levels of miR-132 in the brain of an AD mouse model by intracranial injections of a synthetic miR-132, the two main hallmarks of AD pathology, namely amyloidosis and TAU pathology, are decreased. Part of my project consists of identifying the underlying mechanisms linking the strong downregulation of this microRNA in the brain of AD patients with the progression of the disease. And secondly, since restoring the levels of miR-132 is considered a potential therapeutic strategy, I will optimize the non-invasive intranasal delivery of synthetic miR-132 mimics to the brain in an AD mouse model and assessing the effects of this approach on AD pathology.
Source: Lirias
Author: Walgrave, Hannah
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Identification of dietary modulators of cognitive aging & brain plasticity and proof of concept of efficacy for preventing/reversing cognitive decline, G2144614533, The role of protein aggregate maturation in Alzheimer's disease and other neurodegenerative disorders and its potential for disease monitoring and differential diagnosis., CoEN: Gut microbes, Neuroinflammation and Alzheimer's disease: determining the immunoregulatory role of gut microbiota on brain and behaviour, G7498027273
OpenAlex ID: W7034485966