Cell Free Supernatants of Bifidobacterium: B. adolescentis and B. longum Suppress the Growth in Colorectal Cancer Organoid Model
Year: 2023
Type: dissertation
Abstract: The gut microbiome and its metabolites are pivotal in regulating host metabolism, inflammation, and immunity.Host genetics, colonization at birth, host lifestyle, and exposure to diseases and drugs determine microbial composition.Dysbiosis and disruption of homeostasis in the microbiome have been reported to be involved in the tumorigenesis and progression of colorectal cancer (CRC).However, the role of metabolites secreted by the bacteria in the growth of CRC is still unclear.Here, we compared the microbial composition of CRC patients with healthy controls to identify distinct patterns of microbiota-derived metabolites in CRC.The metagenomic analysis demonstrated that Blautia producta, Bifidobacterium adolescentis, and Bifidobacterium longum decreased, while Parabacteroides distasonis and Bacteroides ovatus were more prevalent in the CRC patient group.Cancer organoid lines were treated with the microbial culture supernatants of these five strains, resulting in considerable cancer growth inhibition and apoptotic effects by Bifidobacterium supernatants.This study demonstrates that the bacterial metabolites depleted in CRC patients may inhibit cancer growth and highlights the effects of microbiome-derived metabolites on CRC growth.
Author: 김민정
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7036417478