Year: 2007
Type: dissertation
Abstract: Stroke is a leading cause of death and disability in the Western world. It is a complex disease \\nresulting from environmental factors and genetic factors, as well as gene-gene and geneenvironment interactions. Many studies have attempted to unravel the genetic aetiology of \\nstroke, but results have been inconsistent. Most have used the candidate gene approach, but \\ngenome-wide linkage analyses have also been performed. Recently, results of genome-wide \\nassociation studies have been reported, however, this approach has not yet been used to \\nstudy the genetics of stroke. Stroke is a heterogeneous disease, which can be subtyped into \\nischaemic stroke (80%) and haemorrhagic stroke (20%), with diff erent underlying pathways. \\nIn order to reduce the complexity of stroke, intermediate phenotypes have been studied, such \\nas hypertension, carotid atherosclerosis and cerebral white matter lesions. Another approach \\nhas been to study stroke in a genetically isolated population.
Author: Marie Josee van Rijn
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W191489185