Work

Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma

Year: 2025

Type: article

Abstract: Oral cancer has been rising in alarming numbers in the world which is anticipated to escalate at 70% by 2030. Although a lot of factors are responsible for the disease, genetics, and gene mutations play a major role in uncontrolled proliferation. Another major factor is apoptosis which is programmed cell death. Apoptosis generally happens in two pathways Extrinsic pathway which involves trans-membrane receptor-mediated interaction and by Intrinsic pathway which is a mitochondrial-initiated event. There are Pro-apoptotic genes that support apoptosis like Caspases, TNF, and P53 families, and Anti-apoptotic genes like BCL-2 which stop the programmed cell death leading to cellular proliferation and tumor progression. This study was done to find the role of the anti-apoptotic protein BCL2 in varying histological grades of oral squamous cell carcinoma by immunohistochemistry.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Subhalakshmi V, Rohit Jaiswal, Indra Priyadharshini K, Ambika Murugesan

Institutions: Vinayaka Missions University, Sardar Patel Post Graduate Institute of Dental and Medical Sciences

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7038601442

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