Work

Investigating the uptake and accumulation of Tau monomers and aggregates in human neurons

Year: 2023

Type: dissertation

Abstract: Pathologic forms of Tau protein transmission between brain cells contribute to neurodegenerative diseases. We generated various Tau species and employed two neuronal models to investigate Tau uptake and accumulation in human neurons. We showed that a higher neuronal accumulation of abnormal Tau aggregates compared to monomers is not associated with different endocytic pathways but with distinct molecular mediators. These findings reveal specific mechanisms for Tau monomer and aggregate uptake and suggest potential targeted interventions for Tauopathies.

Authors: Tayaranian Marvian, Amir, Lichtenthaler, Stefan, Technische Universität München

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Deutscher Akademischer Austauschdienst, Bundesministerium für Bildung und Forschung

Awards: Verbundprojekt: HIT-Tau - Hochdurchsatz-Ansätze für die individualisierte Therapie von Tau-vermittelten Erkrankungen, TP 3, 4: Entwicklung von Analysemethoden + Hochdurchsatz-Screening, G6658192579

OpenAlex ID: W7038607896

Cites: 185

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Related to: 10