Year: 2024
Type: article
Abstract: The article describes a rare clinical case of Lyell's syndrome in a patient with a malignant neoplasm of the sigmoid colon with bilobar metastases to the liver, a history of palliative resection of the sigmoid colon, who was prescribed therapy with the BRAF inhibitor Vemurafenib. While taking the drug, toxic epidermal necrolysis, a generalized form, developed. Toxic epidermal necrolysis (TEN, Lyell's syndrome) is an acute, life-threatening mucocutaneous reaction characterized by skin tenderness, erythema, extensive necrosis and epidermal detachment. The incidence rate is from 0.4 to 1.2 cases per million person-years and mortality up to 50 %. Representatives of the female sex are more often affected. The incidence increases with age and is higher after the fourth decade of life.
Source: Медицина в Кузбассе
Authors: Гарри Сергеевич Погосов, Василий Николаевич Ощепков, Елена Владимировна Рудаева, Владимир Сергеевич Ефетов, Даурен Талгатович Бошатаев, Светлана Ивановна Елгина
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7039582076
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