Ru(II)-catalyzed late-stage C-H amidation of medicinally relevant benzodiazepine scaffold
Year: 2024
Type: report
Abstract: A late-stage C-H functionalization of 1,4-benzodiazepines for direct C-H amidation has been developed via Ru-catalyzed C-H activation. This method efficiently generates medicinally relevant functionalized products using Ru-metal. Tosyl azide serves as a bench-stable amidating reagent. The amidated product is further converted to an aminated product through chemoselective hydrolysis of the sulfonamide bond. In mechanistic studies, ruthenacycle has been synthesized and charac-terized by NMR spectroscopy.
Source: Figshare
Author: John Spencer (4461472)
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7043177148
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