Korzystny wpływ estradiolu na ciśnienie tętnicze, nie na stężenia glukozy i lipidów kobiet z zespołem Turnera
Year: 2016
Type: article
Study design: Observational Study
Abstract: Introduction. Turner syndrome (TS) is the form of gonadal malfunction. Arterial hypertension, elevated LDL and glucose and decreased HDL levels are characteristic of TS-women. Hormone therapy is a treatment for short stature and sex hormone deficits. Hormonal replacement therapy (HRT) reduces the risk of cardiovascular diseases. A large percentage of TS-women do not comply with doctors’ orders regarding HRT. The analysis of 17β estradiol (E 2 ) levels and the assessment of blood pressure, lipid and carbohydrate metabolisms in TS-women it is possible to state whether HRT decreases the risk of cardiovascular diseases? Material and methods. The group of 95 TS-women, who declared HRT, were investigated. The information about HRT was collected during the anamnesis. E2, total cholesterol (TC), high (HDL) and low (LDL) density lipoproteins, triglycerides (TG) and glucose were assessed. Patients were divided into subgroups with E 2 ≥ 110 pmol/L (n = 34) (HE) and < 110 pmol/L (n = 61) (LE) respectively. Results. Arterial hypertension was diagnosed in 26.3%. The groups did not differ in systolic 119 ± 20 versus 118 ± 14 and diastolic 82 ± 13 versus 80 ± 10 mm Hg blood pressure. Despite the higher concentrations of E 2 in HE, no differences were found in weights, lipids and glucose concentrations. Negative correlations between E 2 and body mass (r = –0.25, p = 0.04) and diastolic blood pressure (r = –0.28, p = 0.02) as well as positive between E 2 and glucose (r = 0.24, p < 0.05) were observed only in HE. No correlations between E 2 and lipids were found. Conclusions. 1. Only 1/3 TS-women, who declare HRT, have a satisfactory level of E 2 . In TS-women HRT does not affect glucose and lipid metabolisms. 3. Negative correlation between E 2 and diastolic blood pressure in TS-women suggest beneficial effect of estrogens in hypertension.
Source: Arterial Hypertension
DOI: 10.5603/ah.2016.0023
Authors: Tomasz Jerzy Irzyniec, Wacław Jeż
Language: Polish
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2581066879