Work

Effects of omega 3 fatty acids on vascular function in subjects with Type 2 diabetes mellitus

Year: 2016

Type: dissertation

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: \(\bf Objective:\) We investigated the effects of n-3 FAs on vascular function in subjects with type 2 diabetes mellitus. \(\bf Method:\) In a double-blind, placebo-controlled, randomized, crossover manner, 34 subjects received daily 2 g either n-3 FAs or placebo for 6 weeks. After each therapy, we measured macrovascular (FMD) and microvascular (reactive hyperemia) function fasting as well as following a high fat meal. \(\bf Results:\) Fasting FMD remained unchanged following n-3 FAs or placebo. Postprandial FMD decreased after placebo with 38% - an effect significantly reduced by n-3 FAs supplementation (13%). Postprandial reactive hyperemia remained unchanged after placebo, whereas it improved significantly after n-3 FAs supplementation (maximum increase 27%). Adiponectin and leptin didn´t significantly change after placebo or n-3 FAs. \(\bf Conclusions:\) Our results suggest a protective effect of n-3 FAs on vascular function.

Source: Dokumentenrepositorium der RUB (Ruhr University Bochum)

Author: Nandrean, Simona

Institutions: Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum

Language: English

Topic: Fatty Acid Research and Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: British Heart Foundation, Medical Research Council

OpenAlex ID: W7046624101

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