The Effect of Repetitive Transcranial Magnetic Stimulation on Suicidality in Patients with Treatment Resistant Depression
Year: 2022
Type: dissertation
Abstract: Objective: To investigate the effect of 10Hz repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) on suicidality in patients with treatment resistant depression (TRD).Methods: Data from a three-site randomized clinical trial comparing 10Hz and iTBS rTMS applied to the left dorsolateral prefrontal cortex in patients with TRD was analyzed. The effect of 10Hz rTMS and iTBS on suicidality was compared as measured by the suicide item of the Hamilton Depression Rating Scale 17-item (HDRS-17). Results: Suicidality remitted in 71 (43.7%) of participants randomized to 10Hz stimulation and 91 (49.1%) of participants randomized to iTBS. The difference between the proportions in the two groups (X2 = 0.674, df = 1, p = 0.4117) was not significant. Conclusions: Both 10Hz and iTBS rTMS were effective in reducing suicidality in TRD. Further investigation into the effect of rTMS on suicidality is warranted.
Source: TSpace (University of Toronto)
Author: Mehta, Shobha
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7046992496