Bias in medical biochemistry- what laboratory professionals need to know?
Year: 2021
Type: article
Abstract: In medical laboratories, bias presents quantitative expression of trueness, as \nanalytical performance characteristic that describes systematic errors. Despite bias evaluation \nis an integral part of basic lessons of laboratory quality management, it is still difficult to achieve \nadequate bias estimation in routine laboratory practice. There are several principles that could \nbe used to estimate bias, but fundamental for evaluating bias in routine medical laboratories is \nthe availability of a suitable reference materials. Besides, it is important that the measuring \nmethod and measuring analytical system are in a stable state, and that they have completed \nan appropriate validation or verification process. This could be checked routinely by the results \nof internal and/or external quality control. In addition, information about the uncertainty of the \ncertified reference material is a prerequisite for testing the bias. Significant efforts were made \nto minimized bias in routine laboratory practice, using reference measurement methods and \ncommutable reference materials. Still, there are some challenges that remain for the laboratory \nprofessionals as the end users, due to remaining bias between measurement methods and \nsystems from different and/or the same manufacturers.
Authors: Milinković, Neda, Ignjatović, Svetlana
Language: English
Subfield: Medical Laboratory Technology
Field: Health Professions
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7054814217