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Antioxidant and Anti-inflammatory Meroterpenoids from the Brown Alga Cystoseira usneoides

Year: 2013

Type: article

Abstract: A chemical study of the alga Cystoseira usneoides has led to the isolation of six new meroterpenoids, cystodiones A-F (1-6), together with six known related compounds (7-12). The structures of the new metabolites have been established by spectroscopic techniques. In antioxidant assays all of the tested meroterpenes, and in particular cystodiones A (1) and B (2), 6-cis-amentadione-1'-methyl ether (7), and amentadione-1'-methyl ether (8), exhibited strong radical-scavenging activity. In anti-inflammatory assays, usneoidone Z (11) and its corresponding 6E isomer (12) showed significant activity as inhibitors of the production of the proinflammatory cytokine TNF-α in LPS-stimulated THP-1 human macrophages.

Source: Journal of Natural Products

DOI: 10.1021/np300833y

Authors: Carolina de los Reyes, Hanaa Zbakh, Virginia Motilva, Eva Zubía

Institutions: Universidad de Cádiz, Abdelmalek Essaâdi University, Universidad de Sevilla

Language: English

Topic: Seaweed-derived Bioactive Compounds

Subfield: Aquatic Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2318925482

FWCI: 4.118

Cites: 29

Cited by: 45

Related to: 10