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Calibration free approaches for rapid polymorph discrimination via low frequency (THz) Raman spectroscopy

Year: 2024

Type: article

Abstract: Application of multivariate curve resolution to non-invasive Raman spectra has been investigated for rapid on-line analysis of crystallisation processes and high-throughput screening. Exploring quantification of mefenamic acid solid forms (form I, form II, and dimethylformamide solvate) from the Raman spectra indicated excellent agreement with off-line X-ray analysis.

Source: Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)

Authors: Chong, Magdalene W. S., Ward, Martin R., McFarlan, Catriona, Parrott, Andrew J., Dallin, Paul, Andrews, John, Oswald, Iain D. H., Nordon, Alison

Institutions: Engineering and Physical Sciences Research Council, University of Strathclyde

Language: English

Topic: Spectroscopy and Chemometric Analyses

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W7054966222

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