Interplay Between Childhood Maltreatment, Subclinical Post-Traumatic Stress Symptoms, and IQ: Findings From the EU-GEI Multicentre Case–Control Study
Year: 2024
Type: other
Abstract: Introduction: Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post-traumatic stress symptoms (PTSS), and intelligence has not been investigated. This study investigated the relationship between childhood maltreatment, subclinical PTSS, and intelligence among patients with first-episode psychosis (FEP) and community controls. Methods: Patients with FEP (N = 602) and controls (N = 853) from the EU-GEI study were assessed for childhood maltreatment, PTSS, and intelligence quotient (IQ). Results: PTSS were associated with lower IQ among community controls but not among patients with FEP. In the FEP group, an interaction (p = 0.044) between PTSS and childhood maltreatment on IQ was found, such that the association between PTSS and lower IQ was only present among those exposed to childhood maltreatment. No interaction was evident in controls (p = 0.826). Conclusions: The findings suggest the relevance of cognitive rehabilitation for FEP patients with childhood maltreatment and PTSS.
Source: Apollo (University of Cambridge)
Authors: Sideli, Lucia, Aas, Monica, Alameda, Luis, Trotta, Giulia, La Barbera, Daniele, La Cascia, Caterina, Ferraro, Laura, Velthorst, Eva, Tripoli, Giada, Schimmenti, Adriano, Fontana, Andrea, Quattrone, Diego, Gayer-Anderson, Charlotte, Rodriguez, Victoria, Spinazzola, Edoardo, Stilo, Simona, Seminerio, Fabio, Sartorio, Crocettarachele, Marrazzo, Giovanna, Lasalvia, Antonio, Tosato, Sarah, Tarricone, Ilaria, D'Andrea, Giuseppe, Amoretti, Silvia, Andreu-Bernabeu, Álvaro, Baudin, Grégoire, Beards, Stephanie, Bonetto, Chiara, Bonora, Elena, Cabrera, Bibiana, Carracedo, Angel, Charpeaud, Thomas, Costas, Javier, Cristofalo, Doriana, Durán-Cutilla, Manuel, Ferchiou, Aziz, Fraguas, David, Franke, Nathalie, Frijda, Flora, Llorente, Cloe, Garcia-Portilla, Paz, González Peñas, Javier, Hubbard, Kathryn, Jamain, Stéphane, Jiménez-López, Estela, Leboyer, Marion, López Montoya, Gonzalo, Termorshuizen, Fabian, Van Os, Jim, Rutten, Bart P., EU-GEI WP2 Group, Hersenen-Medisch 1, Brain
Language: English
Topic: Child Abuse and Trauma
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
Funders: Fundación Alicia Koplowitz, Universidad de Sevilla, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades, Instituto de Investigación Sanitaria de Santiago de Compostela, Fondation FondaMental, Amsterdam University Medical Centers, Leverhulme Trust, King's College London, European Commission, Institut National de la Santé et de la Recherche Médicale, Fundação de Amparo à Pesquisa do Estado de São Paulo, Universiteit Utrecht, Universiteit Maastricht, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Rivierduinen, Università degli Studi di Palermo, Universidade de São Paulo, Universitat de Barcelona, Universidad de Oviedo, Centre Hospitalier Universitaire Vaudois, Centro de Investigación Biomédica en Red de Salud Mental, Università degli Studi di Verona, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, Medical Research Council, Economic and Social Research Council, Instituto de Salud Carlos III, National Institute of Mental Health, NextGenerationEU
Awards: G1332902014, The role of the endocannabinoid system and cannabis use in the expression of psychosis, G1520406698, G3210393749, G3426433705, G3764841371, Interacciones genes-ambiente en las trayectorias de salud mental de los jóvenes, Estudio integral de variación genética y molecular de una cohorte española de trastornos del espectro autista y diseño de algoritmos de diagnóstico genético y de biotipos terapéuticos. Cohorte ESTEA., G4937468798, G5543596241, Psychiatric Ratings using Intermediate Stratified Markers 2, G5965028591, Pathways to psychosis among cannabis users, Autism Innovative Medicine Studies – 2 – Trials, G6972650492, Integrating psychological models with biological pathways in psychosis, Enfoque integral y translacional para el diagnóstico genético de TEA: Caracterización clínica, European Network of National Schizophrenia Networks Studying Gene-Environment Interactions, G8824911526
OpenAlex ID: W7057206264
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