Year: 2013
Type: article
Abstract: Patients diagnosed with Glioblastoma multiforme (GBM) only survive a median time of sixteen (16) months through extensive neurosurgery and chemotherapy along with radiation therapy. Research has demonstrated that within a timeframe of five (5) days HNSCs are able to migrate next to the brain tumors in mice. Therefore, it may be concluded that the tumor itself along with surrounding tissue should contain an abundant amount of HNSCs. Integrating this knowledge, a novel GBM therapy may be devised. The long range goal is to remove tumors from GBM patients, isolate the patients Human Neural Stem Cells (HNSCs), transfect them with the PEX gene within a mammalian expression vector and then transplant the patients original HNSCs back into the brain. PEX is part of the C-terminal fragment of MMP2 metalloproteinase shown to prevent "normal biding to alpha-V/bet a-3 and disrupts angiogenesis and tumor growth". The central hypothesis is that after transfection of the patients HNSCs of t
Authors: Sugaya, Kiminobu, Alvarez, Angel, Mount, Stacey
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7058202298