Neuropsychiatric symptoms in Alzheimer’s disease : measurement, follow-up and associations with activities of daily living
Year: 2021
Type: dissertation
Study design: Observational Study
Abstract: Alzheimer's disease (AD) is the most common cause of dementia.The core features of the disease are decline in cognitive functions and activities of daily living (ADLs).However, neuropsychiatric symptoms (NPS), such as depression, apathy and psychosis are also common in AD.NPS associate with worse quality of life and ADLs for the individuals with AD, but also with increasing costs of treatment and burden for caregivers.NPS, however, have received less attention in research than cognitive symptoms.Conflicting results have been reported for associations between NPS and ADLs.The psychometric evidence for commonly used NPS rating scales is limited, and both self-and informant-reports of NPS are used although they provide discrepant information.These factors together complicate accurate detection of NPS and understanding their implications for functional impairment.This study had three aims.First, the associations between NPS and ADLs were examined in a five-year follow-up of people with AD.Next, network structures of affective symptoms in AD, as rated by the person with AD and an informant, were investigated.Finally, the psychometric properties of the most widely used NPS rating scale, the Neuropsychiatric Inventory (NPI), was reviewed.The study used data of people with AD from the University of
Author: Saari, Toni
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G6257040672
OpenAlex ID: W7058461462