NMOSD Mitochondrial Fluorescence Correlates with Ganglion Cell Layer Loss Consistent with Retinal Vasculitis
Year: 2024
Type: article
Abstract: Introduction Fluorescence lifetime imaging ophthalmoscopy (FLIO, Heidelberg Engineering, Figures 1 and 2), a novel in vivo retinal imaging biomarker, generates fluorescence decay lifetimes in 2 spectral channels corresponding to mitochondrial metabolic processes Short Spectral Channel (SSC): 498 – 560 nm Ø Corresponds to flavin adenine dinucleotide (FAD) and oxidative phosphorylation. Long Spectral Channel (LSC): 560 – 720nm Ø Corresponds to predominantly lipofuscin and lysosomal function Based upon animal experimental models and clinical data, mitochondrial dysfunction has a role in the pathophysiology of NMOSD
Source: The Medicine Forum
Authors: Cappellani, MD, Francesco, Markowitz, BS, Daniel M., Affel, MS, Elizabeth, Pulido, MD, Jose S., Fernandez, MD, Brian, Sergott, MD, Robert C.
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7058911045
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