Pengaruh Pemberian Trans Fatty Acid (tfa) Terhadapresistensi Insulin Pada Tikus Galur Wistar
Year: 2016
Type: dissertation
Abstract: Insulin Resistance in the metabolic level is as insufficient insulin function of \nskeletal muscle, liver and adipocytes. This case inhibited the normal role of \nInsulin in which caused increasing muscle cell glucose uptake, glycogen \nsynthesis, and hepatic glucose production discontinuance. The purpose of this \nresearch was to analyze the differences in fasting glucose, fasting insulin and \nHOMA- IR index between the control and experimental group (given by \nmargarine and palm oil with repeatedly heating). This study was true experimental \nresearch by using Post Test Only Control Group Design Research. The sample \nresearch used 25 male wistar strain rats. The data collection was obtained from the \nresult of the laboratory examination of fasting blood glucose and fasting blood \ninsulin to determine HOMA-IR index. The Research result was tested statistically \nby using Manova test at 95% confidence level in SPSS program 16.0 version. The \nresult showed no difference between mean fasting glucose blood (p value = \n0.000), no difference between mean fasting Insulin level and there was \nsignificance difference in HOMA-IR index which determined Insulin Resistance \n(p value = 0.591) on Wistar strain male rats between the control and experimental \ngroup. Advice for public based on WHO recommendation is that TFA \nconsumption recommended < 1 % of the total energy per day should be \nimplemented in order to not causing the adverse for health.
Author: Retno Larasati
Language: Indonesian
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2747359034