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Paying Attention to the Neural Correlates of Attention on Anxiety- and Depression-Related Symptoms

Year: 2022
Type: preprint
Abstract: Poor attention control has been implicated in the development of anxiety and depression-related disorders, and it is a key diagnostic criterion. This study hence aims to understand the effect of attention control on anxiety and depression and the possible neural mechanisms behind this effect. 191 German participants aged 20-80 completed a series of questionnaires as part of the Leipzig Study for Mind-Body-Emotion Interactions. Attention control was measured by the Attention Control Scale; anxiety and depression were measured by the Hospital Anxiety and Depression Scale. Network-based statistics were performed on resting-state functional connectivity data to identify networks positively and negatively correlated with attention control, and mediation analyses were carried out between attention control and both anxiety and depression, with both sets of edges as mediators. Overall, attention control correlated negatively with both anxiety and depression. The attention control-positive network (ACPN) correlated positively with attention control, and negatively with both anxiety and depression. The attention control-negative networks (ACNN) correlated negatively with attention control and positively with both anxiety and depression. The frontoparietal-/dorsal attention-somatomotor connectivity featured prominently in the ACPN, while the ACNN was largely represented by the ventral attention-/dorsal attention-visual connections. Only the ACPN had predictive power as a mediator, mediating the relationship between attention control and anxiety partially, and that of depression completely. Keywords: Resting-state functional connectivity, attention control, depression, anxiety, network-based statistics, mediation analysis
Authors: Loh Raye Fion, Yu Junhong
Language: English
Open Access status: green
OpenAlex ID: W7061195720
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