The potential of Schistosoma-derived substances for use as basis for novel anti-haemostatic therapeutics: : A systematic review
Year: 2021
Type: dissertation
Study design: Systematic Review
Abstract: Background: Parasites belonging to the Schistosoma genus exert an anti-haemostatic net effect upon infection of a definitive host, despite numerous mechanisms that should be pro-haemostatic. The anti-haemostatic mechanisms are thus highly interesting, as they may be leveraged for use as basis for novel anti-haemostatic therapeutics.Aim: The purpose of this systematic review is to provide an overview of research, conducted between 2010 and 2020, on Schistosoma-derived anti-haemostatic substances, as well as studies on Schistosoma-caused coagulation abnormalities, to derive a multifaceted assessment on the potential of Schistosoma-derived substances for use as basis for novel anti-haemostatic therapeutics.Method: Aggregation of publications was done through PubMed using a search string, accompanied by several exclusion criteria. The search string used was as follows: ((Schistosoma coagulation[Title/Abstract]) or (Schistosoma haemostatic[Title/Abstract])) AND ("2010/01/01"[Date - Publication] : "2020/06/01"[Date - Publication])Results: 10 original publications were aggregated: 3 patient studies, 1 murine study and 6 publications on Schistosoma-derived anti-haemostatic substances. Among these, 7 Schistosoma-derived anti-haemostatic substances were found, which were all discovered to be proteases. Conclusion: Out of the 7 proteases, 3 proteases from S. mansoni, namely SmCalp1, SmCalp2 and SmAP, were deemed to have high potential for use as basis for novel anti-haemostatic treatment development. However, research is sparse, so more research is required for a more conclusive assessment. Furthermore, high manufacturing costs of protease-based pharmaceuticals must be considered, by analyzing cost and competition. The other proteases, deemed less interesting, were found to have issues such as low specificity, conflicting pro-haemostatic effects or life-threatening effects if utilized systemically.
Author: Li, Jonas
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7061397181