Work

Tobramycin resistance is less likely to evolve under nitrogen limitation.

Year: 2025

Type: conference-paper

Abstract: I am investigating whether nutrient-limited environments impact the evolution of antibiotic resistance in Escherichia coli. We evolved E. coli for 24 days in nitrogen- or carbon-limited environments with and without tobramycin. Nitrogen-limited populations were less likely to evolve antibiotic resistance as many went extinct before day 24. Growth curves for the evolved and ancestral populations showed that tobramycin-resistant populations grew more slowly than the ancestor in the absence of antibiotics. I also conducted fitness assays to evaluate the competitive ability of the evolved populations compared to their ancestor.

Source: Loyola eCommons (Loyola University of Chicago)

Author: Hofmeier, Anja

Institution: Loyola University Chicago

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7062294861

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