Studies of protein binding to the three prime untranslated region (3'UTR) of glucose transporter mRNA
Year: 2009
Type: dissertation
Abstract: As part of gene exptession within the cell, the regulation of mRNA stability, translation and transport is facilitated by trans-acting proteins that bind to cis-acting signals, present mainly within the 3'UTR. These processes can all contribute to the localisation of a transcript, vital in the development of many eukaryotic cell types, including oocytes, fibroblasts and epithelial cells. The majority of mRNA locahsation studies have concerned mRNAs encoding cytoplasmic proteins. Recent studies, however, have also shown that mRNAs encoding membrane and secreted proteins can also be localised. Recent evidence indicates that these mRNAs may be associated with specific sub-regions of the endoplasmic reticulum (ER) as means of controlling the translation of membrane/secreted proteins, and therefore refining localisation of the mRNA targeting to specific sub-regions of the ER is believed to involve a process independent of signal peptide translation and recognition, and thought to be govemed by signals in the RNA, a number of which have been found in the 3'\\3TR. therefore strongly implicates IMPl in the post transcriptional processing of the SGLTl mRNA and possibly is apical locahsation in enterocytes.
Author: Pedder, Christopher
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7062438120