Year: 2017
Type: article
Abstract: Cancer patients have idiopathic sleep problems that may persist for years after treatment cessation.The underlying contributors to sleep disruption in these patients are not well defined.Differing treatment (e.g., chemotherapy and/or radiotherapy) regimens, heterogeneity among tumor cells and cancer types, as well as social and lifestyle factors (e.g., stress, obesity) could independently promote sleep problems.Mouse models offer a unique opportunity to test the role each of these factors plays in sleep disruption independently, and allow for the direct investigation of candidate mechanisms driving these changes.Therefore, the goal of the work presented herein was to tease apart different potential contributors to sleep disruption in cancer patients, by focusing on cancer treatment (i.e., cytotoxic chemotherapy) and cancer independently.Cancer and the agents used to treat it alter immune signaling that can have wide-reaching effects throughout the body.Neural circuits that control sleep-wake states are sensitive to immune challenges, and can modulate vigilance states in response to inflammation.Because of this, a primary overarching hypothesis for this work was that cancer or chemotherapy-induced inflammatory signaling alters sleep.During the course of this research, the role metabolic factors play in sleep regulation became central to the study of tumor-induced changes in sleep.In Chapter 2, I investigate how non-metastatic mammary tumors contribute to sleep and metabolic disruption.I observed that subcutaneous injection with 67NR murine I acknowledge my advisor, Dr. Randy Nelson, for providing an excellent lab atmosphere and exemplary mentorship.He took a chance in allowing me to work in his lab with limited wet lab experience, and provided me ample opportunities for growth, collaboration, and scholarship.I further thank Dr. Courtney DeVries for letting me pursue these experiments in her lab, and for providing virtually unlimited freedom to explore my scientific ideas and pursuits.I am fortunate to have worked with a group of extraordinary people throughout these years that made coming into the lab each day enjoyable.I thank Drs. Zach Weil and Kate Karelina, for patiently teaching me various techniques and skills and for letting me wander into their office and bother them whenever I was flummoxed.Special thanks are due to Dr.
Author: Borniger, Jeremy C
Institution: The Ohio State University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7065684073