Year: 1956
Type: article
Abstract: 1.In a controlled study of five individuals on isocaloric diets, the Standard s£0-12 a_nd Stan~a.rds~l2-~0 li:poprotei~s are much _hig~er in a diet high in fat of ammal ong1n than with either a diet equally high 1n fat of vegetable origin or a diet low in fat, but supplemented by carbohydrate.With respect to sfO -12 and sFl2 -20 lipoproteins, no significant difference was apparent between the diet low in fat and the diet high in vegetable fat.The difference between animal and vegetable fat appears to be due to an unfavorable effect of animal fat rather than a favorable effect of vegetable fat.2. In the same study, the level of the Standard sf20-400 group of lipoproteins was essentially similar on the diet high in vegetal>le fat to the level on the diet high in animal fat, but distinctly higher on the low-fat, high-carbohydrate diet.The changes in s 0 20...,.400 lipoproteins appear to have been the result of the elevation in carbo~ydrate intake on the low-fat diet.Calories per se appear unimportant, with .respect to this effect, ~ince all diets were is ocaloric.3. A group of subjects in .aweight-reduction study ingested a low-fat, lowcarbohydrate diet.The sf0-12 and s 0 20-400 levels fell on this regimen, ~uggesti~g a_gain that the effect on sfl0-400 lipoproteins obser':ed in the Isocalonc diets had been due to the carbohydrate supplementat10n, rather than to any fat deficiency.4. An egg-yolk supplement equivalent in egg yolk and cholesterol to the high-animal-fat diet in the isocaloric experiment produced minor elevation i~ the s£0-12 lip.oproteins in a group of persons •already on a moderately high ammal-fat mtake.Whether egg yold or cholesterol would produce a larger effect on a low-fat diet or a high-vegetable -fat diet remains unanswered from these data. 5.A dissociation exists between the effects of various dietary measures on the sf0-20 lipoproteins and the sf20-400 lipoproteins.On certain types of diets both classes change in the same direction; on others, the two classes may change in opposite.directions.Since both classes are cholesterol bearers, the dissociation could be obscured if the only analytical measurement available were the serum cholesterol level.
Authors: Nichols, Alex V., Gofman, John W., Dobbins, Virginia., Lawrence Radiation Laboratory., Lawrence Radiation Laboratory.
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7001114006