Year: 2024
Type: dissertation
Abstract: Common Bile Duct (CBD) cancer is a rare malignancy with poor 5-year survival rate and limited treatments available. Genome-wide piggyBac transposon mutagenesis identified Rnf43 as a key gene in CBD development. Mice with Rnf43 KO had shortened survival, supporting its significance and tumor suppressive role. Moreover, organoid culture derived from CBD allowed to conduct a large-scale drug screen, unraveling candidates targeting different molecular pathways. In conclusion, this study supports the tumor suppressive role of Rnf43 and confirmed its importance for WNT pathway.
Authors: Madej, Joanna, Saur, Dieter 1968-, Technische Universität München
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7071121941