Triangulating the evidence for efficacy and effectiveness of antipsychotics by combining randomized clinical trials and real-world data
Year: 2022
Type: preprint
Abstract: The overall aim of this study is to estimate relative effects of antipsychotics for schizophrenia and schizoaffective disorder using evidence on both relative efficacy and real-world effectiveness. Efficacy will be derived from relapse prevention randomized controlled trials (RCTs); real-world (RW) effectiveness will be derived from Finnish and Swedish national registries. Specific aims are to i) compare effect estimates between RCTs and RW; and ii) use results from both RCTs and RW to estimate overall relative effects in a joint analysis of RCT and RW data.
Source: OSF Preprints (OSF Preprints)
Authors: Leucht, Stefan, Vieta, Eduard, Radua, Joaquim, Pinzón-Espinosa, Justo, Algaba, María Ortuño, Vinkers, Christiaan, Tiihonen, Jari, Efthimiou, Orestis, Cardoner, Narcis, Tanskanen, Antti, Schneider-Thoma, Johannes, Fusar-Poli, Paolo, Luykx, Jurjen J, Anneka Tomlinson, Taipale, Heidi, Ellenor Mittendorfer-Rutz, Cipriani, Andrea
Institution: University of Oxford
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6925255455