Consortium analysis of 7 candidate SNPs for ovarian cancer
Year: 2008
Type: article
Abstract: The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer risks. The SNPs selected for analysis were F31I (rs2273535) in AURKA, N372H (rs144848) in BRCA2, rs2854344 in intron 17 of RB1, rs2811712 5' flanking CDKN2A, rs523349 in the 3' UTR of SRD5A2, D302H (rs1045485) in CASP8 and L10P (rs1982073) in TGFB1. Fourteen studies genotyped 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin. A marginally significant association was found for RB1 when all studies were included [ordinal odds ratio (OR) 0.88 (95% confidence interval (CI) 0.79-1.00) p = 0.041 and dominant OR 0.87 (95% CI 0.76-0.98) p = 0.025]; when the studies that originally suggested an association were excluded, the result was suggestive although no longer statistically significant (ordinal OR 0.92, 95% CI 0.79-1.06). This SNP has also been shown to have an association with decreased risk in breast cancer. There was a suggestion of an association for AURKA, when one study that caused significant study heterogeneity was excluded [ordinal OR 1.10 (95% CI 1.01-1.20) p = 0.027; dominant OR 1.12 (95% CI 1.01-1.24) p = 0.03]. The other 5 SNPs in BRCA2, CDKN2A, SRD5A2, CASP8 and TGFB1 showed no association with ovarian cancer risk; given the large sample size, these results can also be considered to be informative. These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach.
Source: International Journal of Cancer
DOI: 10.1002/ijc.23448
Authors: Susan J. Ramus, Robert A. Vierkant, Sharon E. Johnatty, Malcolm C. Pike, David J. Van Den Berg, Anna H. Wu, Celeste Leigh Pearce, Usha Menon, Aleksandra Gentry‐Maharaj, Simon A. Gayther, Richard A. DiCioccio, Valerie McGuire, Alice S. Whittemore, Honglin Song, Douglas F. Easton, Paul D.P. Pharoah, Montserrat Garcia‐Closas, Stephen Chanock, Jolanta Lissowska, Louise Brinton, Kathryn L. Terry, Daniel W. Cramer, Shelley S. Tworoger, Susan E. Hankinson, Andrew Berchuck, Patricia G. Moorman, Joellen M. Schildkraut, Julie M. Cunningham, Mark Liebow, Susanne Krüger Kjaer, Estrid Hogdall, Claus Hogdall, Jan Blaakaer, Roberta B. Ness, Kirsten B. Moysich, Robert P. Edwards, Michael E. Carney, Galina Lurie, Marc T. Goodman, Shan Wang‐Gohrke, Silke Kropp, Jenny Chang‐Claude, Penelope M. Webb, Xiaoqing Chen, Jonathan Beesley, Georgia Chenevix‐Trench, Ellen L. Goode
Institutions: University College London, Mayo Clinic, QIMR Berghofer Medical Research Institute, University of Southern California, Roswell Park Comprehensive Cancer Center, Stanford Medicine, Stanford University, University of Cambridge, Division of Cancer Epidemiology and Genetics, The Maria Sklodowska-Curie National Research Institute of Oncology, Brigham and Women's Hospital, Harvard University, Duke Medical Center, Danish Cancer Society, University of Copenhagen, Rigshospitalet, Aarhus University Hospital, University of Pittsburgh, Magee-Womens Hospital, University of Hawaiʻi at Mānoa, University of Hawaii System, Universität Ulm, German Cancer Research Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Oak Foundation, Minnesota Ovarian Cancer Alliance, California Breast Cancer Research Program, Mayo Foundation for Medical Education and Research, Cancer Research UK, National Institutes of Health, U.S. Public Health Service, National Cancer Institute, Medical Research and Materiel Command
Awards: SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1044543555, UNRESOLVED PUBLIC HEALTH ISSUES RELATED TO HT AND CANCER, SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS PROGRAM, G1440585907, OVARIAN CANCER RISK AND SURVIVAL IN BRCA CARRIERS, G168441794, G1688026025, G1753167306, G1798569254, G1828094709, G2342347956, G2364329658, GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS, The Molecular Epidemiology Of Ovarian Cancer, G3205575695, G3336502132, G3839461529, WS No. 12 Patterns of Care DX Year 2008, G4121987843, G4301672210, G4648664655, G4934827789, Collaborative Genetic Study of Ovarian Cancer Risk, CASE-CONTROL STUDY OF OVARIAN CANCER IN LOS ANGELES, Genetic Susceptibility to Cancer in Multiethnic Cohorts, The Progesterone Receptor Gene and Ovarian Cancer Risk, G5865683244, G6153686719, G64733685, Inflammation and Ovarian Cancer, G6876334999, G6978709651, G7279312517, Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology, G7516052471, G764070827, G835684289, G849639105, G8776526059, G9000349122, Mayo Clinic Comprehensive Cancer Center Support Grant, Roswell Park Cancer Center Support Grant, University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)
OpenAlex ID: W2053323942