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Macrostructural Brain Abnormalities in Spinal Muscular Atrophy A Case-Control Study

Year: 2024

Type: article

Abstract: Background and ObjectivesMost individuals with spinal muscular atrophy (SMA) on disease-modifying therapies continue to have chronic motor impairment.Insights into brain involvement in SMA may open new pathways for adjunctive therapies to optimize outcomes.We aimed to characterize macrostructural brain abnormalities detected by MRI in individuals with SMA compared with peer controls.

Source: eScholarship@McGill (McGill)

Authors: Groulx-Boivin, Emilie, Oliveira-Carneiro, Andrea, Carlson, Helen, Floer, Amalia, Kirton, Adam, Mah, Jean, Saint-Martin, Christine, La Piana, Roberta, Oskoui, Maryam

Institutions: University of Calgary, Alberta Children's Hospital Research Institute, Montreal Children's Hospital, McGill University Health Centre, Research Institute of the McGill University Health Centre, McGill University

Language: English

Topic: Neurogenetic and Muscular Disorders Research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7073681279

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