Polymorphisms in the FGF2 Gene and Risk of Serous Ovarian Cancer: Results From the Ovarian Cancer Association Consortium
Year: 2009
Type: article
Study design: Observational Study
Abstract: Fibroblast growth factor (FGF)-2 (basic) is a potent angiogenic molecule involved in tumor progression, and is one of several growth factors with a central role in ovarian carcinogenesis. We hypothesized that common single nucleotide polymorphisms (SNPs) in the FGF2 gene may alter angiogenic potential and thereby susceptibility to ovarian cancer. We analyzed 25 FGF2 tgSNPs using five independent study populations from the United States and Australia. Analysis was restricted to non-Hispanic White women with serous ovarian carcinoma (1269 cases and 2829 controls). There were no statistically significant associations between any FGF2 SNPs and ovarian cancer risk. There were two nominally statistically significant associations between heterozygosity for two FGF2 SNPs (rs308379 and rs308447; p < .05) and serous ovarian cancer risk in the combined dataset, but rare homozygous estimates did not achieve statistical significance, nor were they consistent with the log additive model of inheritance. Overall genetic variation in FGF2 does not appear to play a role in susceptibility to ovarian cancer.
Source: Twin Research and Human Genetics
Authors: Sharon E. Johnatty, Jonathan Beesley, Xiaoqing Chen, Amanda B. Spurdle, Anna DeFazio, Penelope M. Webb, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer), Ellen L. Goode, David N. Rider, Robert A. Vierkant, Stephanie Anderson, Anna H. Wu, Malcolm Pike, David Van Den Berg, Kirsten Moysich, Roberta Ness, Jennifer Doherty, Mary-Anne Rossing, Celeste Leigh Pearce, Georgia Chenevix-Trench
Institutions: QIMR Berghofer Medical Research Institute, Peter MacCallum Cancer Centre, Mayo Clinic, University of Southern California, USC Norris Comprehensive Cancer Center, Roswell Park Comprehensive Cancer Center, The University of Texas Health Science Center at Houston, Fred Hutch Cancer Center, Royal Brisbane and Women's Hospital
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1044543555, UNRESOLVED PUBLIC HEALTH ISSUES RELATED TO HT AND CANCER, G1355612696, G1688026025, G1753167306, G1798569254, Steroid Hormone Genes and Ovarian Cancer Risk, GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS, CASE-CONTROL STUDY OF OVARIAN CANCER IN LOS ANGELES, Genetic Susceptibility to Cancer in Multiethnic Cohorts, The Progesterone Receptor Gene and Ovarian Cancer Risk, Epidemiology of Ovarian Cancer:New Hypotheses, Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology, G835684289, University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)
OpenAlex ID: W1976528726