Variation at ABO histo‐blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population
Year: 2014
Type: article
Study design: Observational Study
Abstract: ABO blood serotype A is known to be associated with risk of gastric cancer (GC), but little is known how ABO alleles and the fucosyltransferase (FUT) enzymes and genes which are involved in Lewis antigen formation [and in Helicobacter pylori (H. pylori) binding and pathogenicity] may be related to GC risk in a European population. The authors conducted an investigation of 32 variants at ABO and FUT1-7 loci and GC risk in a case-control study of 365 cases and 1,284 controls nested within the EPIC cohort (the EPIC-Eurgast study). Four variants (including rs505922) in ABO, and allelic blood group A (AO+AA, odds ratio=1.84, 95%CI=1.20-2.80) were associated with diffuse-type GC; however, conditional models with other ABO variants indicated that the associations were largely due to allelic blood group A. One variant in FUT5 was also associated with diffuse-type GC, and four variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 with intestinal-type GC. Further, one variant in ABO, two in FUT3 and two in FUT6 were associated with H. pylori infection status in controls, and two of these (in FUT3 and FUT6) were weakly associated with intestinal-type GC risk. None of the individual variants surpassed a Bonferroni corrected p-value cutoff of 0.0016; however, after a gene-based permutation test, two loci [FUT3(Le)/FUT5/FUT6 and FUT2(Se)] were significantly associated with diffuse- and intestinal-type GC, respectively. Replication and functional studies are therefore recommended to clarify the role of ABO and FUT alleles in H. pylori infection and subtype-specific gastric carcinogenesis.
Source: International Journal of Cancer
DOI: 10.1002/ijc.29034
Authors: Eric J. Duell, Catalina Bonet, Xavier Muñoz, Leila Lujan‐Barroso, Elisabete Weiderpass, Marie‐Christine Boutron‐Ruault, Antoine Racine, Gianluca Severi, Federico Canzian, Cosmeri Rizzato, Heiner Boeing, Kim Overvad, Anne Tjønneland, Marcial Argüelles, Emilio Sánchez‐Cantalejo, Saioa Chamosa, José María Huerta, Aurelio Barricarte, Kay‐Tee Khaw, Nick Wareham, Rutch C. Travis, Antonia Trichopoulou, Dimitrios Trichopoulos, Nikos Yiannakouris, Domenico Palli, Claudia Agnoli, Rosario Tumino, Alessio Naccarati, Salvatore Panico, H B(as) Bueno‐de‐Mesquita, Peter D. Siersema, Petra H.M. Peeters, Bodil Ohlsson, Björn Lindkvist, Ingegerd Johansson, Weimin Ye, Matthias Johansson, Claus Fenger, Elio Riboli, Núria Sala, Carlos A. González
Institutions: Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, The University of Melbourne, Cancer Council Victoria, German Cancer Research Center, German Institute of Human Nutrition, Aarhus University, Danish Cancer Society, Gobierno del Principado de Asturias, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Biogipuzkoa Health Research Institute, University of Cambridge, Addenbrooke's Hospital, MRC Epidemiology Unit, University of Oxford, Academy of Athens, Hellenic Health Foundation, Harvard University, Harokopio University of Athens, Istituto per lo Studio e la Prevenzione Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Azienda Usl 8 Arezzo, Italian institute for Genomic Medicine, Federico II University Hospital, University of Naples Federico II, University Medical Center Utrecht, National Institute for Public Health and the Environment, Imperial College London, Lund University, Skåne University Hospital, University of Gothenburg, Umeå University, Centre international de recherche sur le cancer, Odense University Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1930611640