Year: 2004
Type: preprint
Abstract: Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and maturation of vascular smooth muscle cells (vSMC). In adult Notch3-/- mice distal arteries exhibit structural defects and arterial myogenic responses are defective. The postnatal maturation stage of vSMC is deficient in Notch3-/- mice. We further show that Notch3 is required for arterial specification of vSMC but not of endothelial cells. Our data reveal Notch3 to be the first cell-autonomous regulator of arterial differentiation and maturation of vSMC.
Source: Genes & Development
DOI: 10.1101/gad.308904
Authors: Valérie Domenga, Peggy Fardoux, Pierre Lacombe, Marie Monet, Jacqueline Maciazek, Luke T. Krebs, Bernard Klonjkowski, Eliane Berrou, Matthias Mericskay, Zhen Li, Elisabeth Tournier-Lasserve, Thomas Gridley, Anne Joutel
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7075583664