Year: 2025
Type: review
Abstract: Junbo Wang,1 Yu-Jie Liang,2 Xiaohua Pan1 1Department of Orthopaedics and Traumatology, The Second Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 2The Chinese University of Hong Kong, Hong Kong, People’s Republic of ChinaCorrespondence: Xiaohua Pan, The Second Affiliated Hospital of Shenzhen University, No. 118, Longjing 2nd Road, Xin’an Street, Bao’an District, Shenzhen, Guangdong, People’s Republic of China, Email [email protected]: Chronic hyperglycemia over a long period can lead to diabetes-related complications, of which diabetic foot ulcers continue to have a huge economic and social impact worldwide. Mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated positive efficacy in the preclinical research and clinical trial phases of diabetic foot ulcer (DFU) treatment. In this review, we provide a brief overview of the properties of MSC-derived exosomes and their biological functions, summarize the therapeutic efficacy of Exos in the treatment of diabetic foot ulcers and its mechanism of action, and discuss innovative technologies including hydrogel scaffolds and 3D bioprinting to enhance the effectiveness of MSC - Exos in the treatment of diabetic foot ulcers. This paper also explores the application of innovative technologies such as hydrogel scaffolds and 3D bioprinting in enhancing the efficacy of MSC-Exos in the treatment of diabetic foot ulcers and highlights the key challenges faced in translating these advanced technologies from the laboratory to the clinic.Keywords: stem cell-derived exosomes, chronic wounds, diabetic foot ulcers, tissue engineering, translational research
Authors: Wang,Junbo, Liang,Yu-Jie, Pan,Xiaohua
Institutions: Shenzhen University, Chinese University of Hong Kong
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G4549043653
OpenAlex ID: W7075610859
FWCI:
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