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Regional and Cell Specific Bioactivity of Injectable Extracellular Matrix Biomaterials in Myocardial Infarction

Year: 2025

Type: article

Abstract: Myocardial infarction remains a global health concern. To mitigate MI pathophysiology, we previously investigated a pro-reparative decellularized extracellular matrix hydrogel for treating subacute and chronic myocardial infarction. Despite increasing interest in biomaterial scaffolds, single cell and spatially resolved transcriptomics have not been used to probe their therapeutic activity in the heart. Here, we utilize spatial transcriptomics and single nucleus RNA sequencing to delineate the regional and cell-specific bioactivity of extracellular matrix biomaterials.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.16918097

Author: Mesfin, Joshua

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7077074836

FWCI: 0.875

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Cited by: 1

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