Work

Interrupting prolonged sitting reduces postprandial GIP but not GLP ‐1 responses in type 2 diabetes

Year: 2025

Type: other

Abstract: Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two key intestinal-derived incretin hormones with therapeutic potential for glycaemic and weight management.1 Postprandial GLP-1 and GIP potentiate insulin secretion from pancreatic beta cells.1 In type 2 diabetes (T2D), although the insulinotropic effect of GLP-1 is preserved, GIP exhibits aberrant signalling at beta cells, attenuating insulin secretion.1 Breaking up prolonged sitting with brief bouts of activity can improve postprandial glucose, insulin, lipids, and blood pressure responses in T2D2-4; however, the effect of these behaviours on incretin hormone responses in T2D remains unknown. Given the role of incretin hormones in postprandial glycaemic regulation, we examined the potential acute effects of interrupting prolonged sitting with brief bouts of light-intensity walking (LW) and simple resistance activities (SRA) on postprandial GLP-1 and GIP responses in middle-aged and older females and males with T2D.

Source: Apollo (University of Cambridge)

Authors: Beth K Logan (22116145), Robyn Larsen (9900659), Julian W Sacre (19425190), Neale D Cohen (9395413), Gavin W Lambert (13506469), Michael Wheeler (13086588), Neville Owen (370387), Bronwyn A Kingwell (10976010), David Dunstan (13066443), Paddy Dempsey (14682004)

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Deakin University, National Health and Medical Research Council

Awards: Moving More and Sitting Less: Evidence to Inform the Prevention and Management of Type 2 Diabetes, Breaking up prolonged sitting: a practical daily therapeutic tool in the management of type 2 diabetes?

OpenAlex ID: W7077245940

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