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Allergy-assisted passive immunotherapy: Harnessing IgE-mediated responses for cancer treatment

Year: 2025

Type: article

Abstract: Allergy-assisted passive immunotherapy proposes an anti-tumor strategy by transferring allergen-specific immunoglobulin E (IgE) antibodies from atopic donors to cancer patients via transfusion, followed by controlled allergen exposure to induce localized degranulation and inflammation within the tumor microenvironment. This review assesses the biological plausibility, potential mechanisms, and safety considerations of allergy-assisted passive immunotherapy - emphasizing its applicability to immunocompromised patients. While promising, the approach requires rigorous clinical validation.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.16931385

Author: Dochniak, Michael John

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7077276708

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