Work

SolidGel

Year: 2025

Type: article

Abstract: SolidGel is an innovative injectable smart hydrogel platform for localized treatment of solid tumors. It combines hyaluronic acid (HA) with nanoclay (Laponite XLG) and a synergistic drug duo—metformin and disulfiram. The hydrogel enables controlled local release, where metformin starves cancer cells and disulfiram, in the presence of copper, selectively kills resistant cancer stem cells. This approach minimizes systemic toxicity while maximizing therapeutic efficacy, offering a cost-effective and clinically translatable solution for solid tumor therapy.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.16942562

Author: Qudaih, Nadim

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7077562428

FWCI:

Cites:

Cited by:

Related to: