Mechanistic Studies Based on Experimental Xerostomia Models and the Molecular Action of Cinnamaldehyde with Comparative Efficacy of Saliva Substitutes: A Recent Evidence-Based Review
Year: 2025
Type: article
Abstract: Objective: This study aimed to evaluate the effects of cinnamaldehyde and the complementary role of saliva substitutes in a muscarinic receptor antagonist–induced xerostomia model. Methods: In an animal model of xerostomia induced by 4-DAMP, cinnamaldehyde and saliva substitutes were administered individually and in combination. Results: Cinnamaldehyde improved salivary gland tissue structure and increased saliva secretion, while saliva substitutes effectively enhanced oral moisture and alleviated symptoms. Conclusion: Combined treatment showed complementary effects, enhancing overall therapeutic efficacy.
Author: Hee Ja NA1 , Ae eun Moon2
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7078742118
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