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Next-generation Ophthalmic In-situ Gel Systems: Emerging Trends and Innovations

Year: 2025

Type: article

Abstract: Ocular drug delivery poses unique challenges due to anatomical barriers, rapid tear turnover, and poor bioavailability of conventional dosage forms. Ophthalmic in-situ gel systems have emerged as a promising approach, offering prolonged precorneal residence, controlled drug release, and improved patient compliance. Recent advances focus on smart polymers, stimuli-responsive mechanisms, nanotechnology integration, and patient-centric designs to overcome limitations of conventional gels. This review highlights the emerging trends and innovations in ophthalmic in-situ gel systems, including novel polymers, hybrid nanocarriers, clinical applications, and regulatory perspectives, providing future directions for ocular therapeutics.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17053980

Authors: Vivak Bhati*, Deepak Marathia

Institution: Bhupal Nobles University

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7079970287

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