Preparation and in Vitro Evaluation of Self- Micro Emulsifying Drug Delivery System Containing Roxithromycin
Year: 2025
Type: article
Abstract: SMEDDS are isotropic mixtures of oils, surfactants, and co-surfactants which spontaneously form fine oil-in-water emulsions [o/w] , which come over in exposure with GI fluids under suitable agitation and they undergo self-emulsification process. Roxithromycin is a semi-synthetic macrolide antibiotic used to treat a variety of bacterial infections, especially those affecting the respiratory tract, skin, soft tissues, and urinary system. Roxithromycin is a BCS Class IV drug with bioavailability around 50% and it is eliminated with a half-life of 10h. The above research focus on increasing the drug solubility and dissolution rate and various formulations was prepared with SMEDDS ,they depict rapid self-emulsification time, required cloud point values , and acceptable viscosity levels. Overall, this study demonstrated that SMEDDS could significantly improve the solubility, dissolution rate, and bioavailability of roxithromycin, potentially leading to enhanced therapeutic effects.
Author: Dhanya V. O., Aswathi K.*
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7079970985
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